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pentobarbital improves toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may well enhance the metabolism of ifosfamide to its Lively alkylating metabolites.We report a situation of survival next deliberate self-poisoning that has a possibly lethal dose of pentobarbital. In overdose,